摘要
目的研究18FDG PET-CT在鼻咽癌放疗后的应用价值。方法27例鼻咽癌放疗后CT检查发现鼻咽黏膜增厚者在放疗后8-32周行全身18FDG PET-CT检查,并在检查后对全部病例随访12个月以上,所有患者均行纤维鼻咽镜活检。利用PET-CT评价鼻咽癌在放疗后转移及残留,并分析SuV值与预后相关性。结果27例中2例通过PET-CT检查发现远处转移,及时接受相应治疗。以SUV≥2.5作为阳性标准,PET-CT诊断鼻咽癌局部残留20例,其中经病理证实18例;诊断为局部低代谢性病灶7例,病理证实5例。18例被确诊为鼻咽癌局部残留者分别接受鼻咽腔内放疗或立体定向适形放疗。全组患者1年局部控制率为70%,1年总生存率为81%。SUV≥5者11例,1年局部控制率为55%,远处转移率为82%,1年生存率为64%。2.5≤SUV<5者9例,1年局部控制率为67%,远处转移率为22%,1年生存率为89%。两者1年局部控制率和生存率比较差异无统计学意义(P=0.670、0.319),远处转移率差异有统计学意义(P=0.022)。结论18FDG PET-CT对于鉴别鼻咽癌患者放疗后病灶残留具有诊断意义,放疗后局部残留病灶SUV值与远处转移率有关。
Objective To evaluate the role of ^18F fluorodeoxyglucose positron emission tomography computed tomography （PET-CT） in nasopharyngeal carcinoma （NPC） after radiotherapy. Methods A to- tal of 27 NPC patients received ^18FDG PET-CT 8-32 weeks after radiotherapy. All the patients were followed up for about 12 months after the examination. Metastasis and residual were evaluated by PET-CT. The correlation between SUV and prognosis was analyzed. Results Of these 27 patients, metastasis was found in 2 patients by PET-CT. Local persistence was diagnosed as for SUV≥2.5 by PET-CT in 20 patients, among whom 18 were confirmed by biopsy and then received brachytherapy or conformal radiotherapy. One year local control and survival rates were 70% and 81%. Based on SUV, the patients were divided into group one for SUV between 2.5 and 5 （9 patients） or group two for SUV≥5 （ 11 patients）. In group one and group two, the one year local control rate, survival rate and metastasis rate were 67%, 55% （P =0.670）, 64% ,89% （ P = 0.319）, and 22% , 82% （ P = 0.022）, respectively. Conclusions PET-CT is valuable for the identification of residual nasopharyngeal carcinoma. SUV of residual tumor is related to metastasis.
出处
《中华放射肿瘤学杂志》
CSCD
北大核心
2007年第6期411-415,共5页
Chinese Journal of Radiation Oncology
