雷公藤多甙片联合激素和ARB类药物治疗狼疮性肾炎

Nephrotic proteinuria with hormone and ARB on the treatment of lupus nephritis

目的观察雷公藤多甙片联合激素和ARB类药物治疗狼疮性肾炎的近期疗效。方法狼疮性肾炎患者30例接受雷公藤多甙片、泼尼松、缬沙坦片治疗,疗程60 d,治疗结束后评定疗效,并观察24 h尿蛋白定量、血浆白蛋白及治疗中的不良反应等。结果30例中完全缓解18例(60%),部分缓解10例(33.3%),无效2例(6.7%)。患者中部分可见胃肠反应,血细胞升高,停用及对症治疗处理后,恢复正常。结论雷公藤多甙片联合激素和ARB类药物治疗狼疮性肾炎具有较好的疗效。

Objective To observe the short -term therapeutic effect of nephrotic proteinuria with hormone and ARB on the treatment of lupus nephritis. Methods Thirty patients with lupus nephritis were treated with nephrotic proteinuria, prednisone and valsartan. The treatment courses were sixty days and the trerapeutic effect was evaluated after the end of therapy. To investigate the 24 h proteiuria excretion, plasma albumin and the adverse reaction among the treatment. Results Eighteen cases were completely recovery, 10 cases partially remitted and 2 cases no effective among the thirty patients. Acute gastrointestinal reactions were found and blood cells were increased in some patients. But they were normalized after the stop of drugs and expectant treatment. Conclusion Nephrotic proteinuria with hormone and ARB have the definite therapeutic effect on lupus nephritis.