摘要
目的:观察奥沙利铂联合氟尿嘧啶/亚叶酸钙(FFL方案)时辰输注法治疗晚期胃肠道肿瘤的近期疗效和毒性反应。方法:FFL方案时辰输注法治疗32例晚期胃肠道肿瘤患者,奥沙利铂25mg/(m^2·d)(10:00~22:00),氟尿嘧啶600mg/(m^2·d)(22:00~10:00),亚叶酸钙300mg/(m^2·d)(22:00~10:00),分别加5%葡萄糖液至200ml,通过四通道程控时辰输液泵连续给药5天,每21天为1个周期,至少用2个周期。根据世界卫生组织实体瘤化疗判定标准(1981)评价近期疗效。结果:32例患者中,完全缓解(CR)1例(3.1%),部分缓解(PR)14例(43.8%),稳定(SD)13例(40.6%),进展(PD)4例(12.5%),总有效率为46.9%。在共102个周期的化疗中,最常见的不良反应为血液学毒性、胃肠道毒性、外周神经毒性,但均以Ⅰ度为主,Ⅲ度迟发性腹泻发生2例次,未出现Ⅳ度不良反应。结论:FFL方案时辰输注法具有疗效高及毒副作用低等优点,可作为晚期胃肠道肿瘤的推荐化疗方案之一。
Objective: To investigate the efficacy and safety of combination of oxaliplatin ( L-OHP), 5-fluorouracil (5-FU) and folinic acid (LV) in form of chronomodulated chemotherapy for advanced gastrointestinal cancer. Methods:Thirty-two patients received a 5-day chronomodulated infusion of L-OHP, 5-FU and LV. L-OHP(25 mg·m^-2·d^-1 ) infused from 10:00 am to 22:00 pm, and followed by 5-FU (600mg·m^-2·d^-1)and LV (300mg·m^-2·d^-1) from 22:00 pm to 10:00 am for 5 days using a muhichannel programmable pump, every 3 weeks as an cycle for at least 2 cycles according to WHO criteria. Results:One complete and 14 partial remissions were observed in all 32 patients with an overall response rate of 46. 9%. Stable disease was observed in 13 patients (40. 6% ) and progressive disease in 4 ( 12.5% ). A total of 102 cycles were given without any grade 4 toxicity observed, The main toxicities were grade 1 bone marrow suppression, toxicitiy of alimentary canal and neurotoxicity, but grade 3 delayed diarrhea in two patients. Conclusion:Chronomodulated intravenous chemotherapy of oxaliplatin, 5-fluororuacil and folinic acid is effective and safe in the treatment of advanced gastrointestinal cancer.
出处
《临床肿瘤学杂志》
CAS
2007年第11期836-838,共3页
Chinese Clinical Oncology
关键词
晚期胃肠道肿瘤
时辰化疗
疗效
毒性反应
Advanced gastrointestinal cancer
Chronomodulated chemotherapy
Efficacy
Toxicities