(-)-7(R)-羟罗汉脂素的全合成研究

Total Synthesis of (-)-7(R)-Hydroxymatairesinol

以4-戊烯酸及(R)-4-苯基-2-噁唑烷酮为起始原料,以氯化镁在三乙胺和三甲基氯化硅存在下催化的(R)-4-苯基-3-戊烯酰基-2-噁唑烷酮的埃文斯(Evans)反式羟醛缩合反应为关键步骤,经9步反应合成了(-)-7(R)-羟罗汉脂素,其光谱数据与文献报道的天然产物一致.

The （-）-7（R）-hydroxymatairesinol has been synthesized utilizing 4-pentenoic acid and （R）-4- phenyl-2-oxazolidinone as starting materials via the asymmetric aldol reaction of chiral N-acyl-2-oxazolidinone catalyzed by magnesium chloride in the presence of Et3N and chlorotrimethylsilane as the key step in nine steps.