微波对大鼠学习记忆行为的影响

THE EFFECTS OF MICROWAVE ONLEARNING AND MEMORY DEHAVIOR IN RATS

为研究脉冲微波辐照对大鼠学习记忆行为的影响，了解脉冲微波对神经行为的作用，以抛物面集束定向发射X频段脉冲微波，在平均功率密度3～5．8W．cm－2区域进行全身急性辐照，采用一次性被动回避实验—跳台法及主动回避实验—穿梭箱行为训练等行为实验进行观察．结果表明微波辐照1h，大鼠穿梭箱主动回避反应（AAR）学习效率较对照显著降低（P＜0．01）；当大鼠训练至AAR正确率（％）连续3d达80％以上，微波辐照1h，48h后，AAR消退（％）比对照明显加快．有显著性意义（P＜0．01），跳台预训练后微波辐照1h，测验期错误次数明显增加（P＜0．05），比对照组增加5．5倍．说明脉冲微波导致大鼠学习记忆行为障碍．

In order tto investigate the effectts of pulsed microwavesen the nervous system the change of the learning and memory behaviors were observed in rats after they were exposed tox-frequency pulsed microwaves with an average power density of 3-5.8W. cm[2], The rats were first trained with passive avoidance response tests such as stepping down platform and active avoidance response tests such as shuttle-passing box. It was found that the learning efficiency of active avoidance response was significantly lower in the 1st hour after exposure as compared with the control (P<0. 05). When the rats were trained to have a over 80% correctness of active avoidance response for 3 consecutive days The extinction of the correctness achieved was faster in the 1st and 48th hour after exposure to microwaves as compared with the control(p<0. 01). In the 1st hour after exposure,the number of errors of the jumping-down test was 5.5 times higher than that in the contrcl (P<0.01). There were the ultrastructural demages of hippocampus.