二硫化碳接触者肾功能损伤早期监测指标评价

Assessment of Early Biomarker of Renal Damage of Workers Exposed Chronically to Carbon Disulfide

通过对某化纤厂７１名二硫化碳作业工人调查发现，二硫化碳接触工人尿β２－ＭＧ和ＬＤＨ显著高于对照组，且随暴露二硫化碳浓度增高，工龄延长而升高，呈剂量－反应关系。ＡＫＰ和ＡＬｂ则在高浓度组和高工龄段显著高于对照组。表明尿β２－ＭＧ和ＬＤＨ可作为慢性二硫化碳接触者肾功能损伤的早期监测指标。

71 workers exposed to carbon disulfide in a rayon factory and 31 unexposed health workers as controls were investigated.The results showed the levels of urinaria β 2 microglobulin(β 2 MG) and lactate dehydrogenase(LDH) in the exposed group were significantly higher than that of control group,and increased progressively with increasing concentration of carbon disulfide and working years;but alkaline phosphatase (AKP) and albumin(Alb) in high concentration and working year of expoesd group were higher significantly than that of control.That indicated the β 2 MG and LDH may be early biomarkers of renal lesion in chronic carbon disulfide workers.