血管内超声对粥样硬化冠状动脉成像的研究

The Safety and Feasibility of Intravascular UItrasound Imaging of Atherosclerotic Coronary Arteries in Vivo

研究目的在于评价血管内超声（ＩＶＵＳ）观察粥样硬化冠状动脉（ＣＡ）的安全性和可行性。利用３．５Ｆ，３０ＭＨｚ超声导管对１１例冠心病患者的２０支冠状动脉节段进行了检查，所有病人均顺利接ＩＶＵＳ检查，５例血管造影提示冠脉左主干正常的血管段，ＩＶＵＳ显示有内膜轻度增厚或局灶性斑块，１５支血管造影提示ＣＡ管腔狭窄的血管段，ＩＶＵＳ发现有中至重度的内膜增厚，操作中未发现严重并发症。结论：血管内超声检查是安全可行的，它可提供异常ＣＡ管壁形态学的详细信息。

The Purpose of this study was to determine the safety and feasibility of intravascalar ultrasound imaging of atherosclerotic coronary arteries in vivo. 20 coronary segments (LMCA 5, LAD 11, RCA 3, LCX 1) in 11 patients with coronary artery disease were examined using a single element 3.5F, 30 MHz ultrasound catheter. All patients underwent successfully intracoronary ultrasound imaging. 5 LMCA having angiographically normal coronary arterial appearence showed mild intimal thickening (Intemal>0.3 mm) and focal atheroma. All 15 segments (LAD 11, RCA 3, LCX 1) with angiographic evidence of coronary luminal stenoses had moderate(7) or severe(8) intimal thickening detected by IVUS. There is no any complication during IVUS procedures. These data suggest that intravascular ultrasound is safe and feasible and provides detailed images of abnormal coronary wall morphology not previously possible in vivo.