心肌造影超声心动图评估心肌缺血程度的实验研究

Severity of Myocardial Ischemia Using Myocardial Contrast Echocardiography∶A Experimental Study

本实验制作不同程度心肌缺血的动物模型，以声处理５％人血白蛋白为超声造影剂进行心肌灌注造影，探讨ＭＣＥ时间－强度曲线各指标与心肌缺血程度间的关系。结果表明：心肌显影的峰值强度和曲线下面积均与缺血程度呈显著负相关（相关系数分别为ｒ＝－０．９８，Ｐ值＜０．００５；ｒ＝－０．９４，Ｐ值＜０．０５），且能区分轻度、中度和重度三种程度的心肌缺血；而三项时间指标与心肌缺血程度间未发现显著性差异。本实验的初步结果表明，ＭＣＥ是一项活体评估局部心肌血流灌注的有效方法。

This experimental study preparated varying degrees myocardial ischemia in canine model. Myocardial perfusion contrast was perfomed using sonicated 5% human serum albumin as the echocardiographic contrast agent. The relation between myocardial ischemic severity and the parameters derived from time intensity curve of myocardial contrast echocardiography (MCE) were discussed. Myocardial ischemic severity and parameters of peak intensity and area under the time intensity curve (r=-0.98, P<0.005; r=-0.94. P<0.05