硼氟肠道原位灌流对氟吸收及其对血中微量元素的影响

Effect of boron on intestinal fluoride absorption and trace element contents in blood.

本文用原位肠道灌流技术，观察了硼对大鼠肠道氟吸收及其对血中微量元素的影响。实验分为对照组（给氟化水）和实验组（给氟硼混合水），结果表明：灌流后氟可经肠道大量吸收，血氟增加；实验组肠道内有ＢＦ—４络合物形成，血氟增加程度明显低于对照组；对照组血中钙、镁含量明显降低，实验组灌流前后微量元素改变无显著意义。说明：硼可与氟在肠道内形成ＢＦ—４，降低肠道氟吸收量，硼可拮抗氟所致的微量元素的降低。

The effects of boron on intestinal fluoride absorption and trace element content in blood were studied.Sixteen Wistar rats were randomly divided into control group and experimental group.Fluoridated water was perfused in the control,and fluids of fluoride and boron in the experimental,both by means of intestinal perfusion technique in situ.The results of their intestinal fluoride absorption suggested that fluoride could be greatly absorpted in both groups;complex of tetrafluoroborate(BF - 4)was formed in the intestines of the experimental group.However,by comparision,the increase of serum fluoride concentration in the experimental group appeared to be much lesser.After perfusion,the calcium and magnesium contents in blood in the control group decreased significantly,but no significant change in the experimental.It suggested that tetrafluoroborate could be formed in the intestine,and boron would antagonize the decrease of the trace elements by fluoride.