三硝基甲苯作业工人和HBsAg阳性者血清铜蓝蛋白和谷胱甘肽过氧化物酶活性的变化

Changes of ceruloplasmin content and glutathione peroxidase activity in serum of workers exposed to TNT and HBsAg positive subjects.

对河南省某化工厂职业接触ＴＮＴ作业工人现场劳动卫生学调查和健康监护结果表明，车间空气中ＴＮＴ浓度绝大多数超过ＭＡＣ（１ｍｇ／ｍ３），作业工人皮肤污染严重。ＴＮＴ接触组与对照组血清ＧＰＴ活性升高和ＨＢｓＡｇ阳性检出率两组间无显著性差异，表明这两组人群肝功能属于正常范围。同时发现，ＴＮＴ接触组和ＨＢｓＡｇ阳性组血清铜蓝蛋白和谷胱甘肽过氧化物酶活性均极显著低于对照组（Ｐ＜０．０２，Ｐ＜０．００１）；ＨＢｓＡｇ阳性组这两项指标极显著低于ＴＮＴ接触组（Ｐ＜０．０５，Ｐ＜０．０２）。表明ＴＮＴ和ＨＢＶ诱发的肝损伤机理可能部分归因与活性氧生成有关。

The TNT concentrations in air of the workplace mostly exceeded the national maximum allowable concentration(MAC=1mg/m 3)and the skins of the wor kers exposed to TNT were severely contaminated.The serum GPT activity and positive rate of HBsAg in both of exposed TNT and control groups showed no significant differences.However,the content of ceruloplasmin(CP) and activity of glutathione peroxidase(GSH Px)in serum TNT exposed workers and workers with positive HBsAg were lower than those of controls ( P <0.02, P< 0.001),whereas those two indices appeared to be higher in workers with positive HBsAg than in TNT exposed workers.The result suggested that the mechanism of liver damage induced by TNT and HBV might be associated with the reactive oxygen production.