摘要
采用反相乳液法合成了载药淀粉微球。扫描电镜图片表明，淀粉微球呈圆球形，表面粗糙，孔隙发育。红外光谱图存在酰胺基吸收峰，说明可溶性淀粉与N，N’-亚甲基双丙烯酰胺发生了交联反应。循环伏安法分析结果预示淀粉微球对抗坏血酸的富集作用更多地依赖于微球与抗坏血酸分子的氢键缔合作用。引发剂用量、交联剂用量、反应温度、反应时间等因素的改变对微球吸附量有显著的影响。
The drug-carried starch microspheres were synthesized in reversed phrase emulsion system. The photos of SEM indicate that the starch microspheres are spherical particulates with rough surface and inherent pores. The absorption peaks of amide group existed in infrared spectrogram proved that the soluble starch had crosslinked with N, N＇-methylene-bis-acrylamide. The results of cyclic voltammetry suggest that enrichment of starch microspheres to ascorbic acid depends mostly on association reaction of hydrogen bond. It had been confirmed that some parameters influenced obviously the absorption performance of starch microspheres, which included dosage of initiator, dosage of crosslinking agent, reaction temperature and reaction time.
关键词
淀粉微球
反相乳液法
合成
吸附性能
starch microsphere
reversed phrase emulsion system
synthesis
absorption performance
