腺苷脱氨酶检测在肝病患者中的临床应用价值

The Clinic Application Value of the ADA Determination on Liver Disease Patients

【目的】探讨血清腺苷脱氨酶(ADA)在各种肝病患者的变化及临床价值。【方法】用酶偶联比色法测定各类肝病患者及健康对照者血清ADA及丙氨酸氨基转移酶(ALT)的活性,并进行比较法分析。【结果】各种肝病患者ADA、ALT与健康对照组相比均明显升高,肝硬化组ADA升高比ALT升高更为明显。急性肝炎、慢性活动性肝炎、肝硬化患者血清ADA明显高于健康对照组(P<0.01);慢性迁延性肝炎和肝癌患者血清ADA较健康对照组有所升高,但差异无显著性(P>0.05)。【结论】ADA测定对肝脏疾病的诊断具有较高敏感性,对肝病的诊断、鉴别诊断有重要的临床意义。

【Objective】To investigate the change and value of adenosine deaminase（ADA） on various liver disease patients.【Methods】ADA and alanine aminotransferase（ALT） in serum of various liver disease patients and healthy control were measured and compared with colorimetric method of enzymatic couple.【Results】Both the ADA and ALT of various liver disease patients increased significantly,compared with those of the control patients.As to the liver cirrhosis group,the ADA increased more distinctly than the ALT.The ADAs of the patients with acute hepatitis,chronic active hepatitis and liver cirrhosis were evidently higher than those of the healthy control（P〈0.01）;while the ADAs of the patients with chronic persistent hepatitis and liver cancer were slightly higher than those of the healthy control,and there was no statistic difference.【Conclusion】The ADA measuration has relatively high sensitivity on liver disease diagnoses,and has important clinic values on liver disease differential diagnoses.