NT-proBNP在不稳定心绞痛患者危险分层中的作用被引量：2

The Role of N-terminal Pro-B-type Natriuretic Peptide for Risk Stratification in Patients with Unstable Angina Pectoris

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摘要 [目的]探讨NT-proBNP（N-terminal pro-B-type natriuretic peptide）在不稳定心绞痛（UA）患者危险分层中的作用。[方法]选择自2004年2月至2006年1月在本院住院的UA患者218例,所有患者均行心脏彩超和冠状动脉造影检查,左心室收缩功能正常（LVEF〉55%）,没有局部室壁运动异常,肾功能正常。测定所有患者的血浆NT-proBNP和cTnI水平,计算心电图ST段压低数值,按Gensini法计算冠状动脉病变积分。[结果]218例患者中男142例、女76例,年龄52±10.4（44-79）岁。其中中低危患者126例,高危患者92例。与中低危组患者相比,高危组患者NT-proBNP水平、ST段压低程度、cTnI水平和Gensini积分显著升高。按NT-proBNP中位数258ng/L将所有患者分成两组,与低于中位数的患者相比,高于中位数的患者cTnI水平、ST段压低程度和Gensini积分显著升高。NT-proBNP与ST段压低程度、cTnI和Gensini积分呈显著正相关,相关系数分别为0.35、0.329、0.47,均P〈0.01。[结论]NT-proBNP可以作为UA患者早期危险分层的有价值指标,指导临床治疗。 [Objective]To study the role of N-terminal pro-B-type natriuretic peptide for risk stratification in patients with unstable angina pectoris（UAP）.[Methods]Two hundred and eighteen patients with unstable angina pectoris were enrolled since February 2004 to January 2006.All patients were undergone echocardiography and coronary angiography.The level of NT-proBNP,ST segment depression,cTnI and coronary Gensini scores were measured.[Results]There were one hundred and forty two male and seventy six female with age（52±10.4） years old.The level of NT-proBNP,ST segment depression,level of cTnI and coronary Gensini scores of patients in high risk group was significantly higher than those in non-high risk group（all P〈0.01）.The level of cTnI,ST segment depression and coronary Gensini scores were significantly higher in patients with supramedian NT-proBNP than those with inframedian NT-proBNP. The level of NT-proBNP positively correlated with the ST segment depression,the level of cTnI and coronary Gensini scores（r= 0.35、0.33、0.47,respectively.all P〈0.01）.[Conclusion]NT-proBNP may be a valuable marker for early UAP risk stratification.

作者姚海木张晓霞韩智红

机构地区郑州大学第一附属医院心内科北京安贞医院心内科

出处《医学临床研究》 CAS 2007年第7期1118-1120,共3页 Journal of Clinical Research

关键词心绞痛不稳定性 angina,unstable

分类号 R541.105.3 [医药卫生—心血管疾病]

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