培哚普利的降压疗效及其对血管紧张素转换酶与尿N-乙酰-β-D-氨基葡萄糖苷酶的影响

EFFECTS OF PERINDOPRIL ON HYPERTENSION, SERUM ANGIOTENSIN I CONVERTING ENZYME ACTIVITY AND URING LEVEL OF N ACETYL BETA D GLUCOSAMINIDASE

应用新型血管紧张素转换酶抑制剂（ＡＣＥＩ）培哚普利（Ｐｅｒｉｎｄｏｐｒｉｌ）对４０例高血压病患者进行抗高血压临床研究。结果显示：①降压显效率５２．５％，总有效率达８０％；②３０例治疗前后血清ＡＣＥ分别为５８．５±２９．５Ｕ和１８．２±６．９Ｕ（Ｐ＜０．０１）；③２７例治疗后尿ＮＡＧ活性明显降低（Ｐ＜０．０１）；④临床耐受性好。提示该药降压效果显著。

Perindopril 4mg once daily was given to 40 hypertensives for 4 weeks. The results showed that systolic and diastolic blood presure were decreased by 3.2kPa (22.2±2.21～19.0±1.92kPa) and 1.87kPa (13.4±1.21～11.5±1.27kPa), respectively. The total effective rate was 80%. Serum Angiotensin I converting enzyme activity in 30 patients was significantly decreased from 58.5±29.5U to 18.2±16.2U (P<0.01). The urine level of N acetyl beta D glucosaminidase (NAG) in 27 patients significantly decreased from a prior level of 13.66±7.81U·gCr -1 to 10.12±5.57U·gCr -1 (P<0.01). The side effects of perindopril were cough (7.5%), constipation (10%), dizziness (7.5%), flatulence (7.5%) and diarrhea (5%). We conclude that perindopril is a potent antihypertensive drug with significant prevention on hypertension induced early renal damage.