摘要
N^1,N^1-Dimethylbiguanide hydrochloride （HDMBG,HCl） was introduced as an oral glucose-lowering agent to treat non-insulin dependent diabetes mellitus. In this paper, two solid complexes-trichlorotris（N^5-benzoyl-N^1,N^1-dimethylbiguanidato）neodymium, [Nd（BDMBG）3Cl3）, and chlorobis-[N^5-（o-carboxybenzoyl）-N^1,N^1- dimethylbiguanidato]neodymium, [Nd（CDMBG）2Cl], were synthesized and characterized by elemental analyses, fluorescence spectra, IR, UV, DG, DTA etc. Biological testings were conducted by diabetic rats and ESR. The results showed that both the antidiabetic activity and the inhibition rates （Ih） to superoxide anion free radical （O2） on lipid are in the order as follows： Nd（SDMBG）3 [tris（N^5-salicyloyl-N^1,N^1-dimethylbiguanidato）neodymium]〉 Nd（CDMBG）2Cl≈HDMBG·HCl 〉Nd（BDMBG）3Cl3. It was concluded that different substituents at the o-position of the benzoyl group may affect these two kinds of behaviour to a great extent.
N^1,N^1-Dimethylbiguanide hydrochloride （HDMBG,HCl） was introduced as an oral glucose-lowering agent to treat non-insulin dependent diabetes mellitus. In this paper, two solid complexes-trichlorotris（N^5-benzoyl-N^1,N^1-dimethylbiguanidato）neodymium, [Nd（BDMBG）3Cl3）, and chlorobis-[N^5-（o-carboxybenzoyl）-N^1,N^1- dimethylbiguanidato]neodymium, [Nd（CDMBG）2Cl], were synthesized and characterized by elemental analyses, fluorescence spectra, IR, UV, DG, DTA etc. Biological testings were conducted by diabetic rats and ESR. The results showed that both the antidiabetic activity and the inhibition rates （Ih） to superoxide anion free radical （O2） on lipid are in the order as follows： Nd（SDMBG）3 [tris（N^5-salicyloyl-N^1,N^1-dimethylbiguanidato）neodymium]〉 Nd（CDMBG）2Cl≈HDMBG·HCl 〉Nd（BDMBG）3Cl3. It was concluded that different substituents at the o-position of the benzoyl group may affect these two kinds of behaviour to a great extent.
基金
Project supported by the National Natural Science Foundation of China （No. 20171019）.
