喉鳞癌组织中p53和bcl-2的表达及临床意义

Expression of p53 and bcl-2 in laryngeal sqamous cell carcinoma and their clinical significance

目的探讨基因p53与bcl-2在喉鳞癌中的表达及它们的关系,以及它们在喉癌发生、发展中的作用。方法应用免疫组化法测定110例喉鳞癌标本及20例正常黏膜中p53和bcl-2的表达。结果正常黏膜几乎不表达p53及bcl-2,它们在喉鳞癌标本中表达率分别为62.7%和47.3%,p53表达和淋巴结转移情况相关,bcl-2和病理分级、淋巴结转移情况相关;p53和bcl-2表达呈正相关。结论p53和bcl-2关系密切,在喉癌的发生、发展中起重要作用,有望作为早期诊断的指标基因治疗靶点。

Objective To investigate the expression of p53 and bcl - 2 and their relationship, and their roles in the generation and development of laryngeal sqamous cell carcinoma. Methods Immunohistochemical methods was used to study 110 cases of laryngeal carcinoma and 20 cases normal laryngeal tissues to detect the expression of p53 and bcl - 2. Results Among 110 cases of laryngeal sqamous cell carcinoma, the rate of expression of p53 and bcl - 2 were 62.7% and 47.3% ; the expression of p53 was closely correlated with lymph node metastasis and bcl - 2 correlated with pathological grade, lymph node metastasis, p53 expression was related to bcl - 2 expression. Conclusion p53 is closely related to bcl - 2, they plays an important role in tumor expansion and progression and will be the target of gene therapy in laryngeal carcinoma.