H2-calponin在胃癌中的表达及意义

The expression and significance of H2-calponin in gastric carcinoma

目的:研究H2-calponin在胃癌原发灶、癌旁组织及正常组织中的表达、分布及意义,探讨H2-cal-ponin与胃癌发生、分化程度以及侵袭、转移的关系及临床意义。方法:采用免疫组化SP法检测70例胃癌组织,并选取30例癌旁组织及正常胃粘膜组织作为对照进行染色以观察H2-calponin的表达分布和定位情况。结果:H2-calponin在正常胃粘膜、慢性胃粘膜炎(癌旁组织)及胃癌组织中均有表达,其阳性率分别为56.7%、66.7%、58.6%,无显著统计学差异。H2-calponin在伴有淋巴结转移的胃癌组织中的阳性表达率高于无淋巴结转移的胃癌组织中的阳性表达率(P<0.05),具有显著统计学差异;在有浆膜浸润的胃癌组织中的阳性表达率高于无浆膜浸润的胃癌组织中的阳性表达率(P<0.05),具有显著统计学差异;其与患者的年龄、性别和肿瘤的组织分化等因素无关(P>0.05)。肿瘤细胞中H2-calponin均表达于细胞质中。结论:胃癌组织中H2-calponin蛋白的表达与肿瘤侵袭深度和淋巴结转移相关,提示H2-calponin可能与胃癌的转移存在一定的关系。

Objective：To identify the expression and distribution of H2 - ealponin in gastric carcinoma tissues, adjacent tumor tissues（ chronic gastritis） and normal gastric mueosa tissues, and to study the relationship of H2 - ealponin to the biological behavior of gastric carcinoma. Methods： The H2 - ealponin expression was examined by immunohistoehemistry SP method in 70 gastric carcinoma tissues, 30 adjacent tumor tissues （chronic gastritis） and 30 normal gastric mueosa tissues. Results：The positive rates of H2 - ealponin in gastric carcinoma tissues, adjacent tumor tissues （chronic gastritis） and normal gastric mueosa tissues were 56.7% , 66.7% and 58.6% respectively. The difference was not statistically significance among gastric carcinoma tissues, adjacent tumor tissues （ chronic gastritis） and normal gastric mueosa tissues （ P 〉 0.05 ）. The expression of H2 - ealponin protein was positively correlated with the depth of tumor infiltration, lymph node metastasis （ P 〈 0.05 ）, but not related to the degree of histological differentiation and age, sex of patients . Conclusion ： The expression of H2 - ealponin protein was positively correlated with the depth of tumor infiltration, lymph node metastasis of gastric carcinoma .