甲亢患者尿β2-M、Alb水平测定的临床意义

The clinical significance of measurement of urine β2-microglobulin and albium in patients with hyperthyroidism

目的评价检测甲亢患者尿β2-M及Alb水平的临床价值。方法用RIA法测定50例健康志愿者及165例甲亢尿β2-M、Alb水平，并对血清T3、T4、Cre、Urea进行同步检测，对比分析。结果尿β2-M、Alb水平：甲亢初诊组与未缓解组均明显高于对照组及甲亢治愈组（P〈0．01），甲亢未缓解组明显高于初诊组（P〈0．01），甲亢治愈组与对照组无显著性差异（P〉0．05）。甲亢组患者尿β2-M及Alb水平与血清T3水平均有良好的相关性（相关系数分别为0．91，0．93）。结论联合检测尿β2-M及Alb水平对于估计甲亢患者病情的严重程度及早期判断肾脏损伤的部位、程度等有一定的意义。

Objective To study the clinical significance of measurement of urine β2-microglobulin and albium in patients with hyperthyroidism. Methods Levers of urine β2-microglobulin,albium and serum thyroid hormone （including T3,T4）, Cre,Urea of 50 healthy volunteers （as control group） and 165 patients with hyperthyroidism were measured by radioimmunassay （RIA）. Results The levels of urine β2-microglobulin, albium in the patients with hyperthyroidism （including the preliminary diagnosis group and monremittent group） were distinctly higher than those in control group and cured hyperthyroidism group（P〈0.01）;it was distinctly higher in monremittent group than that in preliminary diagnosis group （P〈0.01）, and there was no distinct difference between the control group with cured hyperthyroidism group in urine β2-microglobulin, albium （P〉0.05）.There was favourable correlation between the urine β2-microglobulin, albium with serum T3（the correlative coefficients were 0.91 and 0.93 respectively）. Conclusion It have important significance to measure urine β2-microgiobulin combinding urine aibium in early judgement of the location and degree of the damages of kidney, as well as the severity of disease in patients with hyperthyroidism.