温州地区急性下呼吸道感染衣原体抗原检测的意义

Significance of Chlamydia Detection in Children with Acute Lower Respiratory Tract Infections in Wenzhou Area

目的检测及分析温州地区儿童急性下呼吸道感染性疾病中衣原体感染情况。方法本院2003年11月-2006年6月因急性下呼吸道感染而住院的儿童共708例,采用直接免疫荧光法检测其鼻咽部分泌物中的衣原体抗原,比较不同性别、年龄组、临床疾病诊断及月份间的阳性检出率,分析检测结果。结果检测出衣原体抗原阳性52例（7.3%）。阳性检出率男性[6.9%（37/535例）]与女性[8.7%（15/173例）]比较无显著性差异（χ^2=0.59 P〉0.05）;不同年龄组间阳性检出率以0.5-1.0岁组最高,1-3岁组最低;毛细支气管炎、肺炎、支气管炎患儿阳性检出率分别为4.3%、8.6%、6.5%;各月份阳性检出率以8月份最高,2月份和7月份最低。不同临床疾病诊断、年龄组及月份间的阳性检出率差异均无显著性（Pa〉0.05）。结论温州地区衣原体感染呈散发,无明显的集中流行特点,在引起儿童急性下呼吸道感染性疾病中占一定的比例。

Objective To detect and analyze the epidemics of Chlamydia in children with acute lower respiratory tract infections in Wenzhou area.Methods Chlamydia antigen was detected by direct immunofluorescence assay（DFA） in nasopharyngeal aspirates obtained from 708 hospitalized children suffered from acute lower respiratory tract infections from Nov.2003 to Jun.2006.The detection results were compared and analyzed between different gender,ages,clinical diagnosis and months in consecutive surveyed years.Results Of the 708 cases,52 cases（7.3%）were positive for chlamydia antigen.The positive rate for chlamydia antigen of male and female were 6.9%（37/535） and 8.7%（15/173）.There was no difference between the male and female（χ^2=0.59 P〉0.05）.The most chlamydia infections occurred in the group of 0.5-1.0 years,and the least in the group of 1-3 years,the positive rate for Chlamydia antigen of bronchiolitis,pneumonia and tracheitis were 4.3%,8.6% and 5.5%,respectively.The most chlamydia infections occurred in Aug,and the least in Feb.or July.There was no difference among various clinical diagnosis,ages or months（Pa〉0.05）.Conclusions Chlamydia infections are sporadic without apparent outbreaks in Wenzhou area.Although account for a proportion in children with acute lower respiratory tract infections.