CD40在胃癌中的表达及其临床意义

Expression of CD40 in Gastric Cancer and Its Clinical Significance

[目的]探讨CD40的表达与胃癌临床病理指标的关系。[方法]应用免疫组化技术检测64例胃癌组织中CD40的表达。[结果]CD40在胃癌组织中的阳性表达率为34.4%,明显高于正常组织(χ2=5.9600,P=0.0146);有淋巴结转移的胃癌组织中CD40的阳性表达率高于无淋巴结转移者,但差别无统计学意义(χ2=2.7234,P=0.0989);CD40阳性表达与远处转移及临床分期有关(χ2=9.6333,P=0.0019;χ2=4.2262,P=0.0398),与肿瘤分化程度、浸润深度和瘤块大小均无关,CD40阳性表达者预后差。[结论]CD40在胃癌的发病过程中可能起重要作用,可作为评价胃癌转移及预后的有价值指标之一。

[Purpose] To explore the relationship between CD40 expression and clinicopathologic profiles in gastric cancer. [Methods] The expression of CD40 in gastric cancer tissues was detected immunohistochemically. [Results] The positive expression rate of CD40 in gastric cancer tissue was 34.4%, which was significantly higher than that in normal tissue （Х^2=5.9600, P=0.0146）. The positive expression rate of CD40 in gastric cancer with lymph node metastasis was higher than that without lymph node metastasis （Х^2=2.7234, P=0.0989）. The positive expression of CD40 was significantly correlated with distant metastasis and clinical stage of gastric cancer （Х^2=9.6333, P=0.0019; Х^2=4.2262, P=0.0398）, but not correlated with cancer differentiation, depth of invasion and cancer size. Those cases with positive expression of CD40 revealed poor prognosis. [Conclusion] CD40 might play an important role in the carcinogenesis of gastric cancer and might be a valuable marker in predicting the metastasis and prognosis for gastric cancer.