应用胰岛素样生长因子结合蛋白-1预测早产

Usage of Insulin-like Growth Factor Binding Protein-1 in the Predication of Premature Labor

【目的】评价磷酸化胰岛素样生长因子结合蛋白-1(IGFBP-1)预测早产的有效性。【方法】选取先兆早产孕妇89例及同期相近孕周的正常孕妇48例,运用免疫层析法检测宫颈分泌物中的IGFBP-1。【结果】先兆早产组IGFBP-1阳性率51.69%,对照组IGFBP-1阳性率8.33%,两组差异有显著性(P<0.01);先兆早产组中IGFBP-1阳性46例,一周内分娩率47.83%,阴性43例,一周内分娩率9.30%,两者比较有统计学差异(P<0.01);对照组中IGFBP-1阳性4例,一周内分娩率50.00%,阴性44例,一周内分娩率6.82%,两者比较有统计学差异(P<0.05)。【结论】检测宫颈分泌物中IGFBP-1可作为预测早产的客观指标,其方法简便易行,值得推广。

[Objective] To study the value of phosphorylated isoforms of insulin-like growth factor binding protein-1 （IGFBP-1） in the prediction of premature labor. [Methods] Eight nine pregnant women with threatened premature labor were selected as research subjects, 48 normal pregnant women as controls. IGFBP-1 in cervical secretion was measured by immunochromatography. [Results]In those with threatened premature labor, the positive rate of IGFBP-1 was 51.69%, significantly higher than that of the controls（ P 〈0.01）. In IGFBP-1 positive women of the study group, .22 cases labored within 1 week with an occurrence rate of 47. 83 % which was significantly higher than that of the negative ones（9.30 % ）（ P 〈0.01）. In IGFBP-1 positive women of the control group, 2 labored within 1 week with an occurrence rate of 50. 00% which was higher than that of the negative ones（6.82%） （ P 〈0.05）. [Conclusion] IGFBP-1 can be used in the prediction of premature labor.