甲状腺转录因子-1在喉癌及喉良性病变中的表达

Expression of thyroid transcription factor-1 in laryngeal carcinoma and benign lesion tissues

目的研究甲状腺转录因子-1(TTF-1)在喉癌及喉良性病变中的表达,探讨TTF-1在喉癌发生发展中的意义。方法采用EnV ison方法检测喉癌及其癌旁组织各39例、声带小结13例及声带息肉17例中TTF-1的表达情况。结果喉癌组TTF-1表达强阳性率(48.7%)与喉癌癌旁组织组(12.8%)和对照组(0)比较差异均有统计学意义(P<0.01);喉癌T1N0M0-T1N1M0组TTF-1强阳性率(32.9%)与T2N1M0、T3N2M0组(55.6%、100%)比较差异均有统计学意义(P<0.05);T2N1M0组TTF-1强阳性率(55.6%)与T3N2M0组(100%)比较差异有统计学意义(P<0.05)。结论TTF-1在喉癌中有表达,提示TTF-1可能参与了喉癌的发生和发展。

Objective To investigate the expression of thyroid transcription factor-1 （TTF-1） in laryngeal carcinoma and benign lesion tissues, and to discuss the significance of TTF-1 in the development of laryngeal carcinoma. Methods The expression of TTF-1 in the tissues of 39 cases of laryngeal carcinoma,39 cases of laryngeal peri-carcinoma samples, 13 cases of chorditis nodulosa and 17 cases of polyp of cord was detected by EnVison immunohistochemistry. Results There was significant difference in the expression of TTF-1 in the tissuse of laryngeal carcinoma （48.7 % ） , laryngeal peri-carcinoma （ 12.8% ） and control group（0）. There was significant difference in the expression of TTF-1 in the tissuse of T1N0M0- T1N1M0 group（32.9% ）, T2N1M0 group（55.6% ）and T3N2M0 group（ 100% ）. Conclusion TTF-1 expressed in laryngeal carcinoma tissues may be play an important role in the development of laryngeal carcinoma.