易损斑块标志物和急性冠状动脉综合征

Plasma biomarkers of vulnerable plaque and acute coronary syndrome

急性冠状动脉综合征(ACS)具有很高的发病率和死亡率,严重威胁人类健康。目前已经证实易损斑块的破裂、血小板聚集和继发血栓形成造成冠状动脉急性严重狭窄或闭塞是ACS的主要发病机制。易损斑块的存在是发生ACS的病理基础,而易损斑块的破裂则是ACS发生的始动环节。早期发现易损斑块,及时进行干预,对降低ACS的发病率和死亡率,具有极其重要的临床意义。血清中一些标记物如C反应蛋白、妊娠相关蛋白A等对易损斑块具有早期诊断价值,有助于早期发现ACS高危人群及将来发生的急性心血管事件。作者就检测易损斑块的标志物的研究进展作一综述。

Patients with acute coronary syndromes have a high morbidity and mortality rates, which is a serious health problem. Now it has been confirmed that rupture or erosion of the vulnerable plaque, platelet aggregation and thrombogenesis in the coronary artery is the main pathogenesy of ACS. Vulnerable plaque in coronary artery is the primary pathological basis of ACS. Plaque rupture is the initiating factor of ACS. So it has important clinical significance to find the vulnerable plaques early and take some necessary measures to intervene it for decreasing the morbidity and mortality rates of the patients with ACS. Some plasma biomarkers have been believed the markers of the vulnerable plaques and used to predict the high risk patients and future cardiovascular events in patients with ACS,including high sensitiventy C-reactive protein and pregnancy associated plasma protein-A, etal. This article reviews the new development of the plasma biomarkers of the vulnerable plaque.