支气管哮喘干预措施对气道反应性的影响

Impacts of asthma intervention treatment on airway responsiveness

气道高反应性（AHR）是支气管哮喘（哮喘）的重要特点,多种哮喘干预措施可影响气道反应性。吸入糖皮质激素可明显降低AHR,白三烯调节剂降低AHR的作用弱于吸入糖皮质激素。吸入短效β2受体激动剂对AHR有不利影响,而长效β2受体激动剂对AHR无明显影响。避免过敏原能明显改善职业性哮喘患者的AHR。某些免疫治疗方法可减轻部分哮喘患者的AHR。

A variety of therapeutic interventions make profound impacts on airway hyperresponsiveness（AHR）,a hallmark of bronchial asthma.Inhaled corticosteroids（ICS）,a main controller medication,is the most potent agent in decreasing AHR.Leukotriene modifiers,another important controller medications,have mild to moderate suppressing effect on AHR.While short-acting beta 2-agonists have adverse effects on AHR,there is no evidence that long-term use of long-acting beta 2-agonists could aggravate AHR.Allergen avoidance is associated with attenuation of AHR in occupational asthma and immunotherapy can decrease AHR in some asthma patients.