血吸虫重复感染病人多次接受吡喹酮治疗效果评价

Effect of Repeated Praziquantel Treatment on Re-infected Schistosomiasis Patients

[目的]评价血吸虫重复感染病人多次接受吡喹酮抗虫治疗的效果。[方法]2004～2006年，在镇江市丹徒区江滩型血吸虫病流行区，对2000-2004年接受过吡喹酮抗虫治疗2次及以上的33名血吸虫重复感染病人，采用吡喹酮60mg／kg^2日疗法治疗，并评价其疗效。[结果]接受吡喹酮抗虫治疗6周后，粪便中均未检出血吸虫毛蚴；治疗后第24个月血清血吸虫特异性抗体阳性率由治疗前的100.00%下降至25.24%；治疗2年后B超检查肝脾肿大和肝实质损害的改善不明显。[结论]血吸虫重复感染病人多次接受吡喹酮抗虫治疗效果明显。

[Objective] To access the effect of repeated praziquantel treatment on re-infected schistosomiasis patients. [Methods]33 patients re-infected by schistosomiasis, who received praziquantel treatment at least twice from 2000 to 2004, were treated with a course of qraziquantel dosage of 60 mg/kg/day for two days from 2004 to 2006 in the endemic zone , the effect was evaluated. [Results]6 weeks after the treatment, all subjects were stool-negative; in the 24th month after the treatment,the positive rate of serum specific antibodies dropped from 100% before the treatment to 25.24%;two years after praziquantel treatment,no obvious improvement was found in B mode ultra- sound examination on liver-and-spleen swelling and hepatic parenchyma lesion.[Conclusion]Repeated praziquantel treatment is highly effective in curing patients re-infected by schistosomiasis.