药物肝损害及其诊断

Drug-induced Liver and Its Diagnosis

肝脏是大部分药物转化代谢的场所,一些药物在肝脏代谢时,其本身或其代谢产物可对肝细胞产生直接或间接的毒性损伤。临床上最常见的是特异质性反应,对其机制和临床诊断进行了探讨。

The liver is the majority of medicines transformation metabolism place, when liver metabolism, some medicines itself and its metabolite may have direct or the indirect toxic damage to the liver cell. Most common is idiosyncratic reaction, this article mainly carries on the discussion to its machanism and the clinical diagnosis.