鹿茸生精丸对大鼠睾丸附睾组织质量及血浆睾酮含量影响的实验研究

Experimental study of Lurong Shengjing pill on quality of testiculus and parorchis,testosterone concentration in plasma

目的观察鹿茸生精丸对大鼠睾丸、附睾组织质量及血浆睾酮含量的影响,并探讨其作用机制。方法Wistar健康雄性大鼠30只,随机分为3组,各10只。治疗组予鹿茸生精丸药液,阳性对照组予五子衍宗丸药液,阴性对照组予0.9%氯化钠注射液。各组均每次2 mL灌胃,每日1次,连续15日。给药第16日,用睾酮放射免疫方法测定,计算每mL血浆中睾酮含量。然后摘取各组睾丸与附睾组织称湿质量。结果治疗组附睾组织湿质量及血浆睾酮含量较阴性对照组明显升高,差异有统计学意义(P<0.05)。治疗组比阳性对照组各指标也有所增高,但差异无统计学意义(P>0.05)。结论鹿茸生精丸具有雄激素样作用。

Objective To observe the effect of Lurong Shengjing pill on quality of testieuhis and parorchis, testosterone concentration in plasma,Methods 30 Wistar rats were randomly divided into three groups, Rats in treatment group （ n = 10） were administered Lurong Shengjing pill solution. Rats in positive control group （ n = 10） were administered Wuziyanzong pill solution, Rats in negative control group （ n = 10） were administered 0.9% NaCl solution, The course was 15 days in three groups. In 16 days testosterone concentration in plasma were determined by radioinununity. Wet weight of testiculus and parorchis were weighed. Results Weight of parorchis and testosterone concentration in plasma in treatment group were obvi.ously higher than those in negative control group （ P 〈 0.05）. The indexes in treatment group were high than those in negative control group, but there was no significance between two groups P 〉 0, 05）, Conclusion Lurong Shengjing pill has androgenlike effect,