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乳腺疾病患者血浆VEGF-C水平与乳腺组织中c-erbB-2表达的关系 被引量：2

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摘要 应用酶联免疫吸附试验(ELISA法)检测61例乳腺癌患者和36例乳腺良性疾病患者手术前及12例健康人血浆中VEGF-C的含量,用免疫组织化学法检测乳腺组织中c-erbB-2的表达情况,并进行比较分析。结果示,乳腺癌组血浆VEGF-C(P-VEGF-C)阳性表达率为63.93%,其表达与肿瘤淋巴结转移及临床分期有关(P<0.05),与肿瘤大小、月经状况、雌孕激素受体及组织学分级无关(P>0.05),乳腺癌组VEGF-C高于良性疾病组(P<0.01),VEGF-C的表达水平在导管内癌与浸润性导管癌之间差异有统计学意义(P<0.05),P-VEGF-C与乳腺组织中c-erbB-2的表达呈正相关(r=0.454,P<0.01)。提示乳腺癌患者血浆中VEGF-C表达可能成为鉴别乳腺良恶性病变、判断有无淋巴结转移及预后的辅助指标。
作者 曲兆伟 张建国 张雅芳 郭宝良 沈滨 仲雷
机构地区 黑龙江省哈尔滨医科大学附属二院乳腺外科 哈尔滨医科大学解剖教研室
出处 《中国普通外科杂志》 CAS CSCD 2007年第11期1112-1115,共4页 China Journal of General Surgery
基金 国家自然科学基金资助项目(30672420) 黑龙江省科技攻关项目(2005G0972-00)
关键词 乳腺肿瘤/病理学 血管内皮生长因子C/血液 c—erbB-2
分类号 R737.9 [医药卫生—肿瘤]
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参考文献14

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共引文献27

同被引文献24

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中国普通外科杂志
2007年 第11期

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