摘要
用磷酸三酯法在溶液中合成了两个带有3’－（S）-胸腺嘧啶基-4’－（R）一羟基-5’－（S）-羟甲基四氢呋喃的三脱氧核苷酸3和4．与三脱氧核苷酸（2）相比，化合物3和4对核酸酶SI具有更大的稳定性．
Two trideoxynucleotides incorporated with 3' - (S)- (thymin-1-yl)-4' - (R) -hydroxy-5' -(S)-hydroxymethyl tetrahydrofuran in the 3' end (3) or in center (4) were synthesized via phos-photriester method in solution. Compounds 3 and 4 are stable towards Nuclease S1 compared withthe normal trideoxynucleotides (2).
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1997年第7期1103-1106,共4页
Chemical Journal of Chinese Universities
关键词
酶促稳定性
异核
低聚
核苷酸
合成
Trideoxynucleotide, 3 ' - (S )-(thymin-1-yl)-4' - (R )-hydroxy-5' -(S )-hydro-xymethyltetrahydrofuran, Oligonucleotide, Enzymatic stability
