摘要
目的探讨POMES综合征的临床特征。方法对17例POEMS综合征临床资料、相关检查及治疗方法进行回顾分析。结果本组临床特征与国外组基本一致。不同点为本组病例以多发性周围神经病(100%)、不同程度皮肤改变(100%)为突出表现,常伴肝肿大11例(64.7%),脾肿大14例(82.3%),性腺机能减退较明显11例(64.7%),淋巴结肿大较少7例(41.2%),M蛋白仅3例(17.6%)阳性。12例患者均予激素治疗,4例合用人血免疫球蛋白静滴。结论POMES综合征是一种少见的多脏器损害疾病,早期诊断困难,临床上对可疑病例需进行密切观察和必要的检查,以免误诊。
Objective To evaluate the clinical features of POEMS syndrome. Methods The clinical materials of 17 patients with POEMS syndrome were analyzed retrospectively. Results All 17 patients presented polyneuropathy, edema and hyperpigmented skin. 11 patients were complicated with hepatomegaly, with splenomegalia of 14 cases, with impotence of 11 cases, with enlargement of lymph nodes of 7 cases and abnormal globulinemia of only 3 cases. 12 patients were treated with corticoid , with human immunoglobulin of 4 cases. Conclusion POEMS sysndrome is a rare disease with multiorgan involvement whose diagnosis is difficult. So suspected cases should be given close observation and taken necessary examination to avoid misdiagnosis.
出处
《中国实用神经疾病杂志》
2007年第9期6-9,共4页
Chinese Journal of Practical Nervous Diseases
