Cyclin A与P21蛋白在子宫腺肌病中的表达及临床意义

Study on expression of Cyclin A and P21 in patients with metrial gland diseases and their clinical significance

目的探讨Cyclin A与P21蛋白在子宫腺肌病中的表达及意义。方法采用免疫组织化学的方法(S-P)检测Cyclin A与P21蛋白在子宫腺肌病(40例)及正常子宫内膜组织(30例)中的表达。结果Cyclin A在子宫腺肌病中的表达明显高于正常子宫内膜组织,P21蛋白在子宫腺肌病中的表达明显低于正常子宫内膜组织,差异均有统计学意义(P<0.05)。在子宫腺肌病中,Cyclin A高表达及P21蛋白低表达与异位内膜浸润肌层深度及腺肌瘤的大小有关,而与痛经、月经过多无明显关系。结论Cyclin A及P21蛋白与子宫腺肌病的发生、发展关系密切。

Objective To study the expression of Cyclin A and P21 in patients with menial gland diseases and their clinical significance. Methods Immunohistochemical S-P method was used to detect the expression of Cyclin A and P21 in 40 patients with al gland diseases and in 36 healthy subjects. Results Cyclin A expression levels in patients with menial gland diseases were significantly higher than those of normal endomenial tissue, however, the expression levels of P21 in patients with menial gland diseases were significantly lower than those of normalendomenial tissue（ P 〈 0.05）. The high expression of Cyclin A and the low expression of P21 in menial gland diseases were related with infiltration depth of ectopic endomeniosis and the size of adenomyoma, but were not related with dysmenorrhea and menorrhagia. Conclusion As cell cycle regulatory factors, Cyclin A and P21 might be involved in the pathogenesis and development of menial gland diseases.