三氧化二砷介入治疗骨肉瘤肺转移效果分析

The intervention-therapeutic effect of As_2O_3 on the metastatictumors of lungs in patients with osteosarcoma

目的研究三氧化二砷(As2O3)介入治疗骨肉瘤肺转移的效果。方法对19例骨肉瘤肺转移的患者行股动脉穿刺、血管造影(DSA)后明确肿瘤的位置和范围,将导管头分别置于骨肉瘤供血动脉及支气管动脉内,共注入As2O330mg,1次/疗程,1疗程/月,给予4个疗程。结果骨肉瘤软组织肿块体积缩小50%以上7例,缩小10%～49%9例,骨肉瘤肿瘤软组织肿块体积增大25%以上2例,骨肉瘤肿瘤软组织肿块体积无变化1例;总显效率84.2%。肺转移瘤体积缩小50%以上6例,缩小10%～49%10例,肺转移瘤体积无变化3例,总显效率84.2%。结论应用AS2O3介入治疗对骨肉瘤肺转移的患者近期疗效确切,毒副反应低,具有一定的治疗价值。

Object To observe the intervention therapeutic effect of arsenic trioxide （As203） on the metastatic tumors of lungs in patients with osteosarcoma. Methods 19 osteosarcoma patients with metastatic tumors of the lungs were involved. Femoral artery puncture and digital subtraction angiography（DSA） were conducted to locate the site and range of the tumors. Then two tips of the catheterize was placed into the supplying artery and the bronchial artery respectively. 30mg As2O3 were administered once, with a treatment course of one month. The therapeautic effect was evaluated after four treatment courses. Results The size of the osteosarcoma in 7 patients was reduced more than 50% ,9 cases by 10% -49% .The size of osteosarcoma in 2 patients increased more than 25% and one case didn＇t change at all. The total effective rate was 84.1%. The size of metastatic tumors of the lungs in 6 patients dwindled more than 50%, 10 cases by 10% - 49%. 3 cases didn＇ t chmlge at all. The total effective rate of the metastatic tumors of the lungs was 84.2 %. Conclusion The intervention therapeautic effect of As2O3 cm the metastatic tumors of lungs in patients with osteosareoma is obvious at short-term period, with few side effect.