药用微乳应用概况与发展趋势

Application status and development tendency of the pharmaceutical microemulsion

微乳作为一种新型的药物载体,具有极大的发展潜力。现综述微乳的定义、形成机制、制备方法和特点,并系统综述了近年来微乳在口服、注射、经皮、眼部、鼻腔转运给药制剂等方面的应用概况,以及作为一种技术用于制备固体脂质纳米粒的应用概况,分析了近年来微乳在发展过程中存在的问题,进一步展望了微乳的发展趋势。

Microemulsion has a large development potential as a novel drug vehicle. The circumscription,mechanism,preparation technology and characteristic of the microemulsion were introduced in the paper. The application status of microemuosion in a range of preparations,including oral administration, injection treatment, transdermal delivery, ophthalmic drug delivery, nasal drug delivery, had been systematically reviewed. Also,preparation of solid lipid nanoparticles by microemulsion technique was men- tioned. Some questions of microemuosion were analyzed and the potential development tendency of microemulsion system was also prospected.