摘要
目的探讨垂体催乳素腺瘤中半乳凝素-3-mRNA(Galectin-3-mRNA)表达与腺瘤的临床生物学行为之间的关系。方法选择32例经蝶显微手术切除的垂体催乳素腺瘤患者标本,分侵袭组与非侵袭组,采用显色原位杂交法(CISH)检测石蜡切片标本中Galectin-3蛋白的mRNA。以非参数检验对两种方法检测结果的相关性进行分析。结果侵袭性与Galectin-3的mRNA表达呈显著性相关(相关系数=0.893 P<0.01);Galectin-3-mRNA与血浆PRL水平、腺瘤体积大小相关(相关系数=0.593,0.522 P<0.05)。结论Galectin-3-mRNA表达与对判断侵袭性催乳素腺瘤体积大小、侵袭、血清PRL水平可能有一定的参考价值。
Objective To study the correlation of expression of Galectin-3 mRNA with the biological characteristics and clinical behavior of Prolactinomas. Methods Immunohistochemistry, （IHC） method and chromogenic in situ hybridization （CISH） were used to detect the expression of Galectin-3- mRNA in 32 pituitary adenoma tissue paraffin specimens. Results Galectin-3 -mRNA expression was correlated with clinical sreum prolactin levels and tumor size （ P 〈 0. 05 ）, and Significant correlation （ P 〈 0.01 ） were noted in invasive group. Conclusions Galectin-3 mRNA expression may help evaluate the lesion size and invasiveness, and serum prolactin levels also may help make prognostic judgument for the patients.
出处
《中华神经外科杂志》
CSCD
北大核心
2007年第11期857-860,共4页
Chinese Journal of Neurosurgery
基金
河北省科学技术研究与发展课题基金项目(052761123)
