葛根素对急性脑梗死患者血清IL-6和sICAM-1的影响

Influence of Puerarin on Serum IL-6 and sICAM-1 of Cases with ACI

目的探讨葛根素对急性脑梗死(ACI)患者血清白介素-6(IL-6)和可溶性细胞间粘附分子-1(sICAM-1)的影响。方法66例ACI患者随机分为观察组和对照组。两组均给予常规治疗,观察组加用葛根素治疗2周。观察治疗前后血清IL-6和sI-CAM-1水平的变化,并与正常组比较。结果观察组及对照组治疗前血清IL-6和sICAM-1水平较正常组明显升高(P<0.001),治疗后明显降低(P<0.05),但仍高于正常组(P<0.01),其中观察组下降幅度较对照组大(P<0.001)。观察组及对照组治疗后神经功能缺损评分均较治疗前明显下降(P<0.05),观察组下降幅度更显著(P<0.001)。结论葛根素对脑缺血再灌注损伤有保护作用,其机制可能与抑制IL-6而降低sICAM-1水平有关。

Objective To investigate the influence of Puerarin on serum IL-6 and sICAM-1 of cases with ACI. Methods 66 ACI cases were divided randomly into observation group and control group. Both groups were received medical routine treatment, but the observation group was given Puerarin for two weeks, The changes of serum IL-6 and sICAM-1 were observed before and after treatment. Results The levels of serum IL- 6 and sICAM-1 in observation group and control group were significantly higher than those of normal group before treatment（ P 〈 0.01 ）, but significandy dropped after treatment（ P 〈 0.05）, still higher than normal group （ P 〈 0.01 ） ： The observation group had more decrease than control group（ P 〈 0.001）.qlaere were significantly decrease in nerve functional defect scale in observation group and control group after treatment （ P 〈 0.05） ,while observation group had more decrease than control group（ P 〈 0.001）. Conclusion Puerarin can protect cerebral isehemia-reperfusion injury, and this may relate to the effects of restraining IL-6 and decrease serum sICAM-1.