血清胆红素与动脉粥样硬化性脑梗死的关系研究

The Relationship between Serum Bilirubin and Atherosclerotic Thrombotic Cerebral Infarction.

目的探讨血清胆红素与动脉粥样硬化性血栓性脑梗死(ATCI)的关系。方法测定60例ATCI患者的血清总胆红素、间接胆红素、直接胆红素的水平,应用颈部彩色多普勒超声仪进行颈部血管检测,并与50例健康对照组进行比较。结果ATCI患者血清总胆红素、间接胆红素均低于对照组,两组比较有显著性差异(P<0.05),直接胆红素两组无差异。ATCI组中血清总胆红素(TBIL)>10umol/L者颈动脉斑块和狭窄的发生率分别为50%和21%,TBIL≤10umol/L者颈动脉斑块和狭窄的发生率分别为94%和59%。结论低水平胆红素对ATCI的发生产生不利影响。

Objective To explore the relationship between serum bilimbin and atherosclemtic cerebral infarction （ATCI）. Methods Serum levels of direct bilirubin（DBIL） .indirect bilimbin（IBIL） and total bilimbin（TBIL） were determined in sixty patients of ATCI, with fifty normal healthy people as control group. The presence of carotid atherosclerotic plaque instability was evaluated by color Doppler ultrasound. Results Serum levels of TBIL,IBIL in ATCI patients were sigruificantly lower than those in control group （ P 〈 0.05）, but there was no sigruificant difference in DBIL between two groups （P 〉 0.05）. In ATCI patients, the incidence of carotid atbemselemtic plaque and arteriostensis was 50070, 21 070, respectively, when serum TBIL was higher than 10 umoL/L. The incidence was 94% and 59% in ATCI patients, respectively, when serum TBIL was lower than 10umol/L. Conclusions Low levels of bilimbin have adverse effects on atherosclemtic thrombotic cerebral infarction （ATCI）.