MRI评价药物投递性能方法研究

Noninvasive Visualization of in Vivo Drug Delivery with MRI

采用MRI评价自制肝组织特异性非离子型高分子磁共振造影剂在小鼠体内药物投递效果.分别在注射造影剂后0.1h、6h、12h、24h及7天采集磁共振T1加权图像.所有扫描均在1.5T临床磁共振成像仪上完成,以固定体线圈为射频发射线圈,三英寸圆形表面线圈为信号接收线圈.数据分析前采用线圈非均匀性校正和信号非稳定性校正进行预处理.实验结果显示,线圈空间敏感性校正使得小鼠组织图像信号强度空间更加均匀,稳定性校正后使得图像数据更加准确可靠,MRI是一种在体评价顺磁性标记高分子化合物药物投递效果的有效方法.

Noninvasive visualization of in vivo delivery of liver specific non-ionic polymeric contrast agent in mice was studied with a 1.5 T clinical MRI scanner. Abdominal MR images were acquired immediately, 6, 12, 24, and 168 h （7 day） after injection of the contrast agents with a 3-inch diameter single-loop surface coil. Intensity non-uniformity correction and signal instability correction were performed before data analysis. The results showed that these corrections increased the data reliability and MRI was an effective method for noninvasive visualization of in vivo delivery of paramagnetically labeled polymer conjugates.