局部复发性食管癌三维适形放疗联合化疗的临床研究

A Clinical Study of Three Dimensional Conformal Radiotherapy Combined with Chemotherapy for Recurrent Esophageal Carcinoma After Radical Radiotherapy

目的观察放疗后复发食管癌患者适形放疗联合化疗的疗效。方法2002年6月—2004年12月对76名患者采用适形放疗联合化疗。结果CR 45例(59.2%),PR 23例(30.2%),SD 4例(5.3%),PD 4例(5.3%)。1、2年生存率分别为60.5%、34.2%。死亡原因为局部失败24例(42.9%),远处转移25例(44.6%)。结论对食管癌放疗后复发患者采用适形放疗联合化疗,提高了局控率,有望提高生存率。

Objective To investigate the effects of three dimensional conformal radiotherapy （3-DCRT） combined with chemotherapy in recurrent esophageal carcinoma after radical radiotherapy. Methods From June 2002 to December 2004,76 patients were given 3-DCRT combined with chemotherapy, Results The overall response was 89.5% with CR in 45 patients （ 59, 2% ）, PR in 23 patients （ 30.2% ）, SD and PD in 4 patients（ 5.3% ）. The 1-,2-year survival rates were 60.5% （46/76） , 34, 2% （26/76） respectively. Conclusions In patients with recurrent esophageal carcinoma after radical radiotherapy, 3-DCRT combined with chemotherapy had resulted in promising local control, can increase survival rate.