国产动脉导管未闭封堵器与Amplatzer封堵器在经动脉导管未闭封堵术中应用的疗效比较

The comparison of efficacy of Amplatzer occluder and home-made occluder

目的比较国产动脉导管未闭封堵器与Amplatzer封堵器(美国进口)在经动脉导管未闭(PDA)封堵术中应用的疗效。方法对2006年1月至12月广东省人民医院确诊为PDA的206例患者,110例采用国产封堵器,96例采用Amplatzer封堵器,分别进行PDA封堵术,对比两组的疗效、并发症和费用等情况。结果国产组109例封堵成功(成功率99.1%),进口组95例封堵成功(成功率99.0%)。两组PDA术前各项临床资料指标、手术和X线曝光时间、封堵成功率及住院天数、术后各项并发症发生率比较,差异无显著性意义,两组PDA治疗前后左室舒张末压及心胸比率降低程度差异无显著性意义,治疗总费用国产组明显低于进口组。结论国产PDA封堵器与Amplatzer封堵器相比其疗效、并发症发生率差异无显著性意义,治疗费用低,临床应用前景广泛。

Objective To compare the efficacy of transcatheter closure of patent ductus arteriosus by using Amplatzer occluder and a new home-made occluder. Methods Comparing the efficacy,complications and cost of 110 patients with home-made occluder and 96 patients treated with Amplatzer occluder. Results The case of complete closure：the homemade occluder group was 109（99.1% ） ,the Amplatzer occluder group was 95（99.0% ）, The comparison of preoperatively clinical indexs, operative and exposure time, the rate of complete closure, hospital days and complication were not significantly different. The decrease of left ventricular diastolic and C/T have no significant difference. The total cost of the home-made occluder group was statistically lower than the Amplatzer occluder group. Conclusion Both groups have no significant difference in the efficacy and the rate of complication. The new home-made occluder is low cost and extensive applicative foreground in clinics.