摘要
目的探讨血管瘤的血管生成与促血管生成素家族（Ang/Tie2）之间的关系。方法通过免疫组化SP法、RT-PCR检测增生期血管瘤17例、消退期血管瘤13例和小儿正常皮肤10例的组织中促血管生成素1（Ang1）、促血管生成素2（Ang2）及其受体Tie2的表达情况。结果增生期血管瘤组织Ang2、Tie2表达高于消退期血管瘤（P〈0.01）;Ang2、Tie2在小儿正常皮肤表达较弱或阴性;Ang1在血管瘤和小儿正常皮肤表达均较弱或阴性,二者比较差异无统计学意义（P〉0.05）。结论Ang/Tie2体系在血管瘤的增生和消退过程中可能起重要的作用。
Objective To investigate the relationship of angiogenesis and the Ang family members/receptor（Ang/Tie2） in hemangioma. Methods Expression of Ang1, Ang2 and the receptor Tie2 was detected with immunohistochemical SP method and RT-PCR method in 17 cases of proliferating hemangioma, 13 involuting cases and 10 cases of normal children skin. Results The expression of Ang2 and Tie2 was higher markedly in proliferating hemangiomas than in involuting hemangiomas（P〈0.01）, and was rare or negative in normal skin. Expression of Ang1 was rare or negative both in hemangioma and normal skin without significant difference between them（P〉0.05）. Conclusion Ang/Tie2 system may play an important role in the proliferating and involuting process of hemangioma.
出处
《中华整形外科杂志》
CAS
CSCD
北大核心
2007年第6期515-518,共4页
Chinese Journal of Plastic Surgery
基金
福建省教育厅科研课题（JA05266）
