栎金钱菌活性提取物抗衰老研究

Antiaging effect of the bioactive extract from Collybia dryophila

用栎金钱菌活性提取物灌胃衰老模型小鼠,观察其对小鼠血清SOD活性、肝组织MDA和脂褐素的含量、脾指数、胸腺指数和肾指数的影响。结果表明,栎金钱菌活性提取物能使雄性小鼠血清SOD活性提高40.16%,肝MDA含量减少47.12%,肝脂褐素含量减少89.48%,脾指数增加35.13%,胸腺指数增加48.92%,肾指数增加11.26%,表明栎金钱菌活性提取物具有良好的抗衰老作用。栎金钱菌活性提取物800mg/kg·d的剂量具有最好的抗衰老效果,且具有性别的差异,对雄性小鼠的抗衰老作用略优于对雌性小鼠的。

D-galactose induced aging mice were fed with the bioactive extract from Collybia dryophila. Spleen, thymus and kidney indexes, SOD activity in serum, MDA and lipofuscin level in liver were measured. The results showed that SOD activity in serum, spleen, thymus and kidney indexes of male mice fed with 800mg/kg·d of the bioactive extract from Collybia dryophila were respectively increased by 40.16%, 35.13%, 48.92% and 11.26%, while MDA and lipofuscin content in liver decreased by 47.12% and 89.48% respectively as compared with the models. It is concluded that the bioactive extract from Collybia dryophila has obvious antiaging effect.