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巨噬细胞炎性蛋白-1α在多发性骨髓瘤发病机制中的作用 被引量：1

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摘要 巨噬细胞炎性蛋白-1α（MIP-1α）是一种C-C趋化因子，由骨髓瘤细胞产生，通过剂量依赖性途经直接刺激破骨细胞形成和分化，刺激浆细胞的增殖、迁移和存活，促进骨髓瘤细胞与骨髓基质细胞之间的粘附作用，增加核因子-κB受体活化因子配体和白细胞介素-6的表达。MIP-1α蛋白水平在多发性骨髓瘤患者骨髓浆中较高，并与疾病的分期及活动状况有关。本文就MIP-1α的生物学特性、生物学效应及其在多发性骨髓瘤中的作用作一综述。
作者 赵娟（综述） 邹萍（审校） 陈智超（审校）
机构地区 华中科技大学同济医学院附属协和医院血液病研究所
出处 《国际输血及血液学杂志》 CAS 2007年第6期540-542,共3页 International Journal of Blood Transfusion and Hematology
关键词 巨噬细胞炎性蛋白 多发性骨髓瘤
分类号 R733.705 [医药卫生—肿瘤]
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参考文献19

  • 1Jones E, Price DA, Dahm-vicker M, et al. The influence of macrophage inflammatory protein-lalpha on protective immunity mediated by antiviral cytotoxic T cells. Immunology, 2003, 109 (1):68-75.
  • 2Mikawa AY ,Malavazi I ,Tagliavini SA,et al. The beta-chemokines MIP lalpha and RANTES and lipoprotein metabolism in HIV- infected Brazilian patients. Braz J Infect Dis, 2005,9(4):315-323.
  • 3Stringer SE,Forster MJ,Mulloy B,et al. Characterization of the binding site on heparan sulfate for macrophage inflammatory protein lalpha. Blood, 2002,100(5) :1543-1550.
  • 4Toh K, Kukita T ,Wu Z,et al. Possible involvement of MIP-lalpha in the recruitment of osteoclast progenitors to the distal tibia in rats with adjuvant induced arthritis. Lab Invest, 2004,84 (9): 1092-1102.
  • 5Han JH, Choi SJ, Kurihara N, et al. Macrophage inflammatory protein-lalpha is an osteoclastogenic factor in myeloma that is independent of receptor activator of nuclear factor kappaB ligand. Blood, 2001,97 (11 ):3349-3353.
  • 6Lean JM,Murphy C,Fuller K,et al. CCL9/MIP-1 gamma and its receptor CCR1 are the major chemokine ligand/receptor species expressed by osteoclasts. Journal of Cellular Biochemistry, 2002, 87 (4) : 386-393.
  • 7Terpos E, Politou M, Rahemtulla A. New insights into the pathophysiology and management of bone disease in multiple myeloma. Br J Haematol,2003,123(5) :758-769.
  • 8Choi SJ, Oba T, Callander NS, et al. AML-1A and AML 1B regulation of MIP lalpha expression in multiple myeloma. Blood, 2003,101(10): 3778-3783.
  • 9Choi SJ ,Oba Y ,Gazitt Y,et al. Antisense inhibition of macrophage inflammatory protein-1 alpha blocks bone destruction in a model of myeloma bone disease. J Clin Invest ,2001,108(12) : 1833-1841.
  • 10Oyajobi BO, Franchin G, Williams PJ, et al. Dual effects of macrophage inflammatory protein-1 alpha on osteolysis and tumor burden in the murine 5TGM1 model of myeloma bone disease. Blood,2003,102(1): 311-319.

同被引文献14

  • 1Najjar V A,Constantopoulos A.A new phagocytosis-stimulating tetrapeptide hormone,tuftsin,and its role in disease[J].J Reticuloendothel Soc,1972,12(2):197-215.
  • 2Najjar V A,Nishioka K.“Tuftsin”:a natural phagocytosis stimulating peptide[J].Nature,1970,228(5272):672-3.
  • 3Nishioka K.Anti-tumour effect of the physiological tetrapeptide,tuftsin[J].Br J Cancer,1979,39(3):342-5.
  • 4贾娜.小鼠术后残瘤模型的建立及T肽抑制术后残瘤生长的初步研究[D].北京:军事医学科学院,2010.
  • 5An Y,Li L,Yang D,et al.Anticancer activity of tuftsin-derived T peptide in postoperative residual tumors[J].Anticancer Drugs,2014,25(8):857-67.
  • 6Mantovani A,Sozzani S,Locati M,et al.Macrophage polarization:tumor-associated macrophages as a paradigm for polarized M2mononuclear phagocytes[J].Trends Immunol,2002,23(11):549-55.
  • 7Mantovani A,Schioppa T,Porta C,et al.Role of tumor-associated macrophages in tumor progression and invasion.[J].Cancer Metastasis Rev,2006,25(3):315-22.
  • 8Hsu C J,Wu M H,Chen C Y,et al.AMP-activated protein kinase activation mediates CCL3-induced cell migration and matrix metalloproteinase-2 expression in human chondrosarcoma[J].Cell Commun Signal,2013,11(68):.
  • 9Schoppmann SF1,Birner P,Stckl J,et al.Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis[J].Am J Pathol,2002,161(3):947-56.
  • 10O'Reilly M S,Holmgren L,Shing Y,et al.Angiostatin:a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma[J].Cell,1994,79(2):315-28.

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国际输血及血液学杂志
2007年 第6期

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