辅酶Q_(10)补充对青少年运动员肝线粒体功能和有氧运动能力的影响

EFFECTS OF COENZYME Q_(10) SUPPLEMENTTATION ON LIVER MITOCHONDRIAL FUNCTION AND AEROBIC CAPACITY IN ADOLESCENT ATHLETES

目的:观察CoQ10补充对青少年运动员肝线粒体功能和有氧运动能力的影响。方法:18名进行耐力训练的男性青少年游泳运动员单盲随机分为Q组及P组,分别补充CoQ10100mg/d或安慰剂28d。结果:①补充后Q组血浆CoQ10浓度显著增高,且显著高于P组;②补充后Q组安静状态的血浆MDA水平无显著改变,且显著低于P组;③首次恒定负荷运动后总体血浆CoQ10浓度较安静状态显著降低;④总体血浆CoQ10基础浓度与首次递增负荷运动中测定的V.O2max显著正相关;⑤补充前后在1h耐力运动中动脉血酮体比的改变程度Q组与P组无组间差异;⑥Q组与P组.VO2max、个体乳酸阈和运动节省化的改变程度无组间差异。结论:尽管急性耐力运动中机体对CoQ10的需求增加,CoQ10补充也可降低血浆脂质过氧化水平,外源性CoQ10不能改善青少年运动员的肝线粒体功能和有氧运动能力。

To investigate the effects of CoQ10 supplementation on liver mitochondrial function and aerobic capacity in adolescent athletes. Methods： Rased on a single blinded study design, 18 male adolescent swimming athletes were randomized into two groups, supplement CoQ10 100 mg/d （Q group）, or placebo（P group） for 28 days respectively. Results： （1）After supplementation, the plasma CoQ10 concentration in Q group was significantly elevated and significantly higher compared to P group. （2）After supplementation, the rest plasma MDA level in Q group remained unchanged and was significantly lower compared to P group. （3）The plasma CoQ10 concentration of the 18 athletes was significantly decreased during the first constant endurance exercise. （4）The baseline plasma CoQ10 of the 18 subjects showed significantly positive correlation with VO2max measured in the first incremental exercise. （5）No significant difference of increased level of AKBR between Q group and P group. （6）No significant difference of increase level of VO2 max, individual lactate threshold and exercise economy between Q and P group. Conclusion： Although there is an increased demand for plasma CoQ10 during endurance exercise and CoQ10 supplement can depress lipid peroxidation, there is no effect of CoQ10 supplementation on liver mitochondrial function and aerobic capacity in adolescent athletes.