摘要
目的:研究吗啡对胎动、心率、孵化率、孵化时间、雏鸡体重等的影响。方法:以气室给药的方式给鸡胚注射吗啡,记录胎动、心率、孵化率、孵化时间、雏鸡体重。结果:吗啡可以缩短雏鸡的孵化时间,降低雏鸡的孵化率,并导致雏鸡出现运动障碍;20mg/kg吗啡剂量和12-16胚龄的给药时间,鸡胚孵化率最高,残疾率最低;吗啡导致胚胎心率加快,胎动减少(P<0.05)。结论:吗啡对胚胎发育有损伤作用,损伤程度与吗啡剂量和给药时间有关。
To investigate the effect of morphine on fetal movement, heart rate, hatch weight, hatch days and hatch rate. Methods： Morphine was injected into airspace of eggs and fetal movement, heart rate, hatch weight, hatch days and hatch rates were recorded. Results： Hatch days were shorter, hatch rates were lower and some chicks became motor disorder for morphine. Chicks with morphine exposure 20 mg/kg from E 12 to E 16 had highest hatch rate and lowest disable rate. Morphine reduced fetal movement, increased heart rate （P 〈 0.05）. Conclusion： The development of chick embryo is impaired by morphine exposure and the magnitude of these effects depends on the drug dose and the length of time that the developing organism is exposed to morphine.
出处
《中国应用生理学杂志》
CAS
CSCD
北大核心
2007年第4期500-504,共5页
Chinese Journal of Applied Physiology
基金
国家自然科学基金资助项目(30470553)
关键词
吗啡
鸡胚胎
心率
胎动
morphine
chick embryo
heart rate
fetal movement
