期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

CD24及其免疫调节与免疫耐受诱导作用 被引量：4

CD24 and Its Functions in Immune Regulation and Immune Tolerance
原文传递
导出
摘要 CD24是一种低分子量高度糖基化膜糖蛋白,主要表达在大多造血细胞和脑组织,发挥重要功能。最新研究显示,CD24协同刺激T细胞活化,促进其增殖,也参与自身免疫性疾病的发生。而且随着不同细胞型别和生物学环境的变化,CD24也起着诱导凋亡或促进树突状细胞的免疫耐受作用。 CD24 is a small, heavily glycosylated cell surface protein that is expressed in a variety of hematopoietic cells and neurocytes thereby playing a variety of important roles. CD24 has been demonstrated to provide co-stimulatory signals to T cells, promote T cell proliferation and partake in the pathogenesis of autoimmune diseases （ AIDs ）. Depending upon cell types and microenvironment, CD24 can induce apoptosis and induce immune tolerance in dendritic cells （DCs）.
作者 庄建良 黄荣金 潘群雄
机构地区 福建医科大学附属泉州第一医院肿瘤外科
出处 《医学分子生物学杂志》 CAS CSCD 2007年第6期541-544,共4页 Journal of Medical Molecular Biology
关键词 CD24蛋白 免疫调节 免疫耐受 CD24 immunoregulation immunotolerance
分类号 R392.11 [医药卫生—免疫学]
  • 相关文献

参考文献28

  • 1[1]HOUGH M R,ROSTEN P M,SEXTON T L,et al.Mapping of CD24 and homologous sequences to multiple chromosomal loci[J].Genomics,1994,22(1):154-161.
  • 2[2]ZHOU Q,GUO Y,LIU Y.Regulation of the stability of heat-stable antigen mRNA by interplay between two novel cis elements in the 3'untranslated region[J].Mol Cell Biol,1998,18(2):815-826.
  • 3[3]HAINES J L,TER-MINASSIAN M,BAZYK A,et al.A complete genomic screen for multiple sclerosis underscores a role for the major histocompatability complex.The multiple sclerosis genetics group[J].Nat Genet,1996,13(4):469-471.
  • 4[4]DUPERRAY C,BOIRON J M,BOUCHEIX C,et al.The CD24 antigen discriminates between pre-B and B cells in human bone marrow[J].J Immunol,1990,145(11):3678-3683.
  • 5[5]ISRAEL E,KAPELUSHNIK J,YERMIAHU T,et al.Expression of CD24 on CD19-CD79a + early B-cell progenitors in human bone marrow[J].Cell Immunol,2005,236(1-2):171-178.
  • 6[6]CHAPPEL M S,HOUGH M R,MITTEL A,et al.Cross-linking the murine heat-stable antigen induces apoptosis in B cell precursors and suppresses the anti-CD40-induced proliferation of mature resting B lymphocytes[J].J Exp Med,1996,184 (5):1638-1649.
  • 7[7]HOUGH M R,CHAPPEL M S,SAUVAGEAU G,et al.Reduction of early B lymphocyte precursors in transgenic mice overexpressing the murine heat-stable antigen[J].Cell Immunol,2005,236(1-2):171-178.
  • 8[8]TAGUCHI T,KIYOKAWA N,MIMORI K,et al.Pre-B cell antigen receptor-mediated signal inhibits CD24-induced apoptosis in human pre-B cells[J].J Immunol,2003,170(1):252-260.
  • 9[9]HOUGH M R,TAKEI F,HUMPHRIES R K,et al.Defective development of thymocytes overexpressing the costimulatory molecule,heat-stable antige.J Exp Med,1994,179(1):177-184.
  • 10[10]LIU Y,JONES B,BRADY W,et al.Co-stimulation of murine CD4 T cell growth:cooperation between B7 and heat-stable antigen[J].Eur J Immunol,1992,22 (11):2855-2859.

二级参考文献10

  • 1Teutsch SM, Booth DR, Bennetts BH, et al. Association of common T cell activation gene polymorphisms with multiple sclerosis in Australian patients. J Neuroimmunol, 2004, 148 : 218-230.
  • 2Hutloff A, Dittrich AM, Beier KC, et al. ICOS is an inducible T-cell co-sitimulator structurally and functionally related to CD28.Nature, 1999, 397: 263-266.
  • 3Richter G, Burdach S. ICOS: a new costimulatory ligand/receptor pair and its role in T-cell activion. Onkologie, 2004, 27: 91-95.
  • 4Rottman JB, Smith T, Tonra JR, et aL The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE. Nat Immunol, 2001, 2: 605-611.
  • 5Kenealy SJ, Pericak-Vance MA, Haines JL. The genetic epidemiology of multiple sclerosis. J Neuroimmunol, 2003, 143 : 7-12.
  • 6Haaning Andersen AD, Lange M, Lillevang ST. Allelic variation of the inducible costimulator (ICOS) gene: detection of polymorphisms, analysis of the promoter region, and extended haplotype estimation. Tissue Antigens, 2003, 61 : 276-285.
  • 7Zhou Q, Rammohan K, Lin S, et aL CD24 is a genetic modifier for risk and progression of multiple sclerosis. Proc Natl Acad Sci U S A,2003, 100: 15041-15046.
  • 8Pahan K, Schmid M. Activation of nuclear factor-KB in the spinal cord of experimental allergic encephalomyelitis. Neurosci Lett,2000. 287 : 17-20.
  • 9Eisenhaber B, Bork P, Eisenhaber F. Sequence properties of GPI-anchored proteins near the omega-site : constraints for the polypeptide binding site of the putative transamidase. Protein Eng, 1998, 11:1155-1161.
  • 10Bai XF, Li O, Zhou Q, et aL CD24 controls expansion and persistence of autoreactive T cells in the central nervous system during experimental autoimmune encephalomyelitis. J Exp Med,2004, 200: 447-458.

共引文献1

同被引文献68

  • 1万毅刚,孙伟,陈晓艳,杨海明,葛明,戴玮,清水不二雄.雷公藤多苷对抗Thy1.1抗体肾炎肾小球内炎症细胞浸润的抑制作用[J].中国中药杂志,2009,34(1):72-77. 被引量：16
  • 2盛锋,沈国权,孙武权.神经根型颈椎病疗效评价量表的研究近况[J].中西医结合学报,2010,8(9):824-828. 被引量：70
  • 3Page DL, Ellis IO, Elston CW. Histologic grading of breast cancer. Let's do it[J]. Am J Clin Pathol, 1995, 103(2) :123-124.
  • 4Kristiansen G, Schlu K, Yongwei Y. CD24 is an independent prognostic marker of survival in nonsmall cell lung cancer patients [J]. Brit J Cancer, 2003, 88:231-236.
  • 5Liu Y, Zheng P. CD24 : a genetic checkpoint in T cell homeostasis and autoimmune diseases[J]. Trends Immunol, 2007, 28(7): 315-320.
  • 6Baumann P, Cremers N, Kroese F, et al. CD24 expression causes the acquisition of multiple cellular properties associated with tumor growth and metastasis [ J ]. Cancer Res, 2005, 65 ( 23 ) : 10783- 10793.
  • 7Smith SC, Oxford G, Wu Z, et al. The metastasis-associated gene CD24 is regulated by Ral GTPase and is a mediator of cell prollferation and survival in human cancer [ J ]. Cancer Res, 2006, 66 (4) :1917-1922.
  • 8Kim HJ, Kim JB, Lee KM, et al. Isolation of CD24(high) and CD24(low/-) cells from MCF-7:CD24 expression is positively related with proliferation, adhesion and invasion in MCF-7 [ J ]. Cancer Lett, 2007, 258( 1 ) :98-108.
  • 9Surowiak P, Matema V, Gyrffy B, et al. Multivariate analysis of oestrogen receptor alpha, pS2, metallothionein and CD24 expression in invasive breast cancers [ J ]. Br J Cancer, 2006, 95 (3) : 339-346.
  • 10Friederichs J, Zeller Y, Hafezi-Moghadam A, et al. The CD24/P- selectin binding pathway initiates lung arrest of human A125 adenocarcinoma ceils [ J ]. Cancer Res, 2000, 60 ( 23 ) :6714 -6722.

引证文献4

二级引证文献30

医学分子生物学杂志
2007年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部