期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

生长分化因子-5与骨骼发育 被引量：2

Growth/Differentiation Factor-5 and Skeletal Development
原文传递
导出
摘要 生长分化因子属于骨形态发生蛋白信号分子高度保守的亚家族,对骨骼的发育具有至关重要的作用。近年报道表明:生长分化因子-5(growth/differentiation factor-5,GDF-5)的羧端区域与GDF-6和-7高度同源。GDF-5在治疗肌腱或韧带修复,椎间盘退变修复,软骨修复,骨折愈合等方面具有潜在应用价值。 The growth/differentiation factors （GDFs） are a subfamily of the highly conserved group of bone morphogenetic protein （BMP） signaling molecules known to play a variety of roles in the skeletal system. It was recently found that GDF-5 was highly homologous in the C-terminal signaling regions of GDF-6 and GDF-7. GDF-5 may have potential to be used in the repair of tendon/liga- ment, degenerative intervertebral discs and cartilage repair and bone healing.
作者 刘振宁 贾长青 韩长旭
机构地区 中国医科大学盛京医院脊柱与关节外科
出处 《医学分子生物学杂志》 CAS CSCD 2007年第6期545-548,共4页 Journal of Medical Molecular Biology
基金 辽宁省科技计划项目(No.2006408002-4)~~
关键词 生长分化因子-5 肌腱 椎间盘 骨骼 神经元 GDF-5 Tendon Intervertebral disk Skeleton Neuron
分类号 R68 [医药卫生—骨科学]
  • 相关文献

参考文献32

  • 1[1]NICKEL J,KOTZSCH A,SEBALD W,et al.A single residue of GDF-5 defines binding specificity to BMP receptor IB[J].J Mol Biol,2005,349(5):933-947.
  • 2[2]MIKIC B,CLARK R T,BATTAGLIA T C,et al.Altered hypertrophic chondrocyte kinetics in GDF-5 deficient murine tibial growth plates[J].J Orthop Res,2004,22(3):552 556.
  • 3[3]SUTO J.Identification of mutation in the growth differentiation factor 5 (Gdf5) gene in NC-brp/brp mice[J].J Vet Med Sci,2006,68(10):1121-1124.
  • 4[4]TAKAHARA M,HARADA M,GUAN D H.Developmental failure of phalanges in the absence of growth/differentiation factor 5[J].Bone,2004,35(5):1069-1076.
  • 5[5]SZCZALUBA K,HILBERT K,OBERSZTYN E,et al.Du Pan syndrome phenotype caused by heterozygous pathogenic mutations in cdmp1 gene[J].Am J Med Genet,2005,138(4):379-383.
  • 6[6]DOBBS M B,GURNETT C A,ROBARGE J,et al.Variable hand and foot abnormalities in family with congenital vertical talus and CDMP-1 gene mutation[J].J Orthop Res,2005,23(6):1490-1494.
  • 7[7]DAWSON K,SEEMAN P,SEBALD E,et al.GDF5 is a second locus for multiple-synostosis syndrome[J].Am J Hum Genet,2006,78(4):708-712.
  • 8[8]KJAER K W,EIBERG H,HANSEN L,et al.A mutation in the receptor binding site of GDF5 causes Mohr-Wriedt brachydactyly type A2[J].J Med Genet,2006,43(3):225-231.
  • 9[9]DEMIRHAN O,TURKMEN S,SCHWABE G C,et al.A homozygous BMPR1B mutation causes a new subtype of acromesomelic chondrodysplasia with genital anomalies[J].J Med Genet,2005,42(4):314-317
  • 10[10]HARADA M,TAKAHARA M,ZHE P,et al.Developmental failure of the intra-articular ligaments in mice with absence of growth differentiation factor 5[J].Osteoarthritis Cartilage,2007,15(4):468-474.

同被引文献17

  • 1Poiraudeau S, Monteiro I, Anract P,et al. Phenotypic characteristics of rabbit intervertebral disc cells :comparison with cartilage cells from the same animals[ J ] . Spine, 1999,24:837 - 844.
  • 2Kanaya K,Tsuchida Y, Inobe M, et al. Combined gene therapy with adenovirus vectors containing CTLA41g and CD401g prolongs survival of composite tissue allografts in rat model [ J ]. Transplantion, 2003, 75:275 -281.
  • 3Hotten G, Neidhardt H ,Jacobowsky B,et al. Cloning and expression of recombinant human growth and diff erentiation factor - 5 [ J ]. Biothem Biophys Res Commun, 1994,204:646 - 652.
  • 4Mikic B. Multiple effeets of GDF - 5 deficiency on skeletal tissues : implications for therapeutic bioengineering[ J ]. Ann Biomed Eng, 2004, 32:466 - 476.
  • 5Wang H, Krueber M, Hanke M ,et al. Release of active and depot GDF -5 after adenovims - mediated overexpression stimulates rabbit and human intervertebral disc eells [ J ]. J Mol Med, 2004,82:1262 - 1341.
  • 6Li X, Leo BM, Beck G,et al. Collagen and protenglycan abnormalities in the GDF - 5 - deft cient mice and molecular changes when treating disk cells with recombinant growth factor[ J]. Spine,2004,29:2229 - 2234.
  • 7Walsh AJ, Bradford DS, Lotz JC. In vivo growth factor treatment of degenerated intervertebral discs[ J]. Spine ,2004,29 : 156 - 163.
  • 8Chujo T, An HS,Akeda K,et al. Eft ects of growth differentiation factor-5 on the intervertebral disc - in vitro bovine study and in vivo rabbit disc degeneration model study [ J ]. Spine, 2006,31 : 2909 - 2917.
  • 9朱建福,刘国辉.椎间盘退变基因治疗的研究进展[J].中国矫形外科杂志,2007,15(21):1635-1637. 被引量：3
  • 10林智军,刘航涛,王万明.椎间盘内注射生长分化因子5及成骨蛋白1对椎间盘退变影响的研究进展[J].中国修复重建外科杂志,2008,22(4):435-438. 被引量：7

引证文献2

二级引证文献4

医学分子生物学杂志
2007年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部