乳头隐匿性分泌液中CEA的检测在乳腺肿瘤鉴别诊断中的意义

Detection of CEA from nipple occult secretions in diagnosis of breast tumors

目的分析检测乳头隐匿性分泌液中CEA的表达及其在乳腺肿瘤鉴别诊断中的意义。方法对34例乳腺癌患者,26例乳腺良性疾病患者作乳头分泌液CEA检测;将硝酸纤维膜贴附于乳头上24小时,取下后低温保存,使用免疫组化方法对吸附于膜片上的CEA进行检测。结果34例乳腺癌患者中12例膜片中出现CEA染色,而良性疾病患者26例中仅1例。两组差异有显著性(P<0.01)。结论硝酸纤维膜可吸附乳头分泌液中的微量抗原,对其中CEA的检测有可能作为一种乳腺良、恶性肿瘤鉴别诊断的辅助方法。

Objective To evaluate detection of CEA from nipple occult secretions in diagnosis of breast tumors. Methods Sixty patients were recruited in the study including 34 with breast carcinoma and 26 with benign tumor. The nitrocellulose membrane disk was affixed on the nipple area for 24 hours. The CEA absorbed on the disk was detected by immunoassay. Results In 34 patients with breast carcinoma, 12 showed clear immunostaining of CEA on absorbent disks; while only 1 of 26 with breast benign tumor showed positive staining. There was significant difference between two groups （P 0. 01）. Conclusion Immuno-assay for CEA in nipple occult secretions may be a useful means to discriminate between malignant and benign tumors of the breast.