米非司酮在多囊卵巢综合征中的应用

Mifepristone in the treatment of polycytic ovary syndrome

目的:探讨米非司酮在多囊卵巢综合征中的治疗作用。方法:将100例多囊卵巢综合征患者随机分两组,每组各50例,一组服用米非司酮,另一组服用二甲双胍,待促黄体生成素/促卵泡刺激素比例恢复或接近正常时再使用促排卵药枸盐酸氯米芬。B超监测两组患者排卵情况及随访患者受孕情况,分别统计两组患者排卵率和受孕率。结果:服用米非司酮组50例患者45例排卵(90%)、39例受孕(78%);服用二甲双胍组50例患者37例排卵(74%),29例受孕(58%)。结论:服用米非司酮组患者的排卵率和受孕率明显高于服用二甲双胍组。服用米非司酮药物经济方便,无毒副作用,可常规用于多囊卵巢综合征患者的治疗。

Objective To evaluate the therapeutic effect of mifepristone in the treatment of polycytic ovary syndrome. Methods One hundred patients with polycytic ovary syndrome were randomly divided into two groups. Each group had 50 patients. Before the application of ovulation induction drugs, one group was given mifepristone while the other metformin. Clomiphene citrate was applied to each group when the proportions of LH /FSH were close or returned to normal. The pregnancy and ovulation of each group were monitored with ultrasonic diagnostic set. Results Of the 50 patients treated with mifepristone, 45 cases （90%） experienced ovulatin in which 39 （78%） got pregnant; while of the 50 patients treated with metformin, 37 （74%） experienced ovulation, in which 29 （58%） got pregnant. Conclusion The pregnancy rate and ovulation rate of mifepristone group are higher than metformin group. Mifepristone, inexpensive and without obvious adverse reation, can widely be used in the treatment of polycytic ovary syndrome.