EGF、VEGF在常见消化道肿瘤患者血清中的表达及意义

The expressions of serum EGF and VEGF in common malignant gastrointestinal tumors and the significance

目的:检测常见消化道肿瘤(食管癌、胃癌、大肠癌)患者血清中表皮生长因子(EGF)与血管内皮生长因子(VEGF)浓度,探讨EGF、VEGF在消化道肿瘤患者血液中的表达、二者之间的关系及意义。方法:应用酶联免疫技术(ELISA法)检测102例常见消化道肿瘤患者和39名健康人血清中EGF、VEGF浓度。结果:102例消化道肿瘤患者血清EGF含量为1.69±0.50μg/L,VEGF含量为298.38±0.29 pg/ml;39例正常对照组血清EGF含量为0.74±0.81μg/L,VEGF含量为84.30±0.22 pg/ml(P<0.05)。结论:消化道肿瘤患者血清EGF、VEGF浓度显著高于健康对照组,且二者呈显著正相关。

Objective： To explore the levels of serum epidermal growth factor （EGF） and vascular endothelial growth factor （VEGF） in common malignant gastrointestinal tumor （esophageal cancer, gastric cancer and colon cancer） and the relation of the two factors. Methods： The serum EGF and VEGF levels were measured by enzyme - linked immunosorbent assay （ELISA） in 102 patients with tumors and 39 healthy subjects respectively. Result. The serum EGF level of malignant gastrointestinal tumor patients was 1.69 ± 0.50 μg/L and VEGF level was 298.38 ± 0.29 pg/ml ;The serum EGF level of healthy persons was 0.74 ± 0.81μg/L and VEGF level was 84.30 ± 0.22 pg/ml（P 〈 0.05）. Conclusion： Serum levels of EGF and VEGF ard significantly higher in patients with malignant gastrointestinal tumor than in healthy controls （P 〈 0.05 ）. There is obvious positire correlation between EGF and VEGF.