组织内泵入式化疗给药系统初探

Elementary Research For A System of chemotherapy through the local tissue

目的:探讨通过局部组织吸收化疗药物的靶向控释给药系统的安全性与可行性。方法:自制植入式化疗给药泵装置,并植入实验兔体内,将5-Fu持续、直接释放于兔子的肌肉和皮下组织内,设立自身两侧对照,不同时间取材,病理检验给药与非给药后的组织改变,统计评价两者之间的差异。结果:给药与非给药后的组织病理改变差异无统计学意义。结论:组织内低浓度缓慢泵入5-Fu,依靠局部组织吸收,进行化疗这一控释给药靶向系统是安全可行的。

Objective： To explore the efficacy of a new target drug delivery system. Methods： At first , a kind of implantable transfusional pumps for chemotherapy were made, and were implanted in the body of rabbits. 5 -Fu was inputted slowly and continuously into musculature or hypodermis, when any rabbit died, the varieties of pathology were detected. Results： There was no statistically significant difference between experimental sections and control experimental sections, which shoed that the new measure was safe and feasible. Conclusion： The approach of transfusion is secure and feasible.